Prediction of fracture initiation and propagation has significant engineering applications in preventing catastrophic crack-induced failures in structures. One particularly important type of fracture is ductile cracking, observed in materials such as metals, concrete, rock, and various composites. Ductile cracking is a complex process in which materials undergo gradual damage evolution, often characterized by plastic deformations […]

Title: Statistical and Information Theoretic Methods for Brain and Brain-Body Coupling Abstract: Coupling between neural oscillations has been extensively studied within the context of cognition and neurological conditions such as Parkinson’s disease, autism spectrum disorder, and depression. More recently, such couplings have been observed between the electrical rhythms of the gut and the brain. Understanding […]

Title: High-throughput affinity measurements of direct interactions between activation domains and co-activators Abstract: Sequence-specific activation by transcription factors is essential for gene regulation(Ptashne 1988; Mitchell and Tjian 1989). Key to this are activation domains, which often fall within disordered regions of transcription factors(Ravarani et al. 2018; Már et al. 2023) and recruit co-activators to initiate […]